History

Celiac disease (CD) is an autoimmune gastrointestinal ailment brought on by the ingestion of peptides found in wheat, rye, barley, and potentially oats in people who are genetically predisposed to developing the disease. Gluten, the cohesive protein mass generated by washing wheat dough to remove starch and other water-soluble components, has been labelled as dangerous proteins. Celiac disease is poorly known, including its method of presentation and immune response mechanism. To better understand the immunological response generated by celiac disease, this study analysed the demographic and clinical characteristics of 200 patients with whole blood and serum from the disease. ELIZA and qPCR were also used to measure the amount of IL-2 in the gene and serum at different stages of disease. The finding shows that IL-2 is an important part of the immune response at different stages of disease. The data showed that the titters of people with a new disease were much higher than those of healthy people. However, the titters of healthy people didn't change when they were treated or kept away from gluten. It seems that IL-2 may have a direct role with celiac disease not only at the first stage of diseases but also at relapsed cases.