Evaluation Role of IL-17 and Some Hematological Markers in COVID-19 Infection
Department of microbiology / College of Medicine/ University of Al-Qadisiyah/ Iraq.
2 Department of microbiology / College of Medicine/ University of Al-Qadisiyah/ Iraq.
Department of microbiology / College of Medicine/ University of Al-Qadisiyah/ Iraq.
Abstract
Background
Clinical evidence suggests that the fatal outcome observed with severe acute respiratory syndrome-2 often results from alveolar infection impairing airway capacity and multi-organ failure that associated with an overactive immune response. Present study aimed to evaluation role of IL-17, Dimer, lymphocytes, WBC, hemoglobin and platelets in COVID-19 infection.
Methods
This case – Control study included 100 patients diagnosed with COVID-19 and 100 healthy individuals as control group. Quantitative determination of Human IL-17 performed by ELISA assay. ARCHITECT auto analyzer is fully automated device used to determine D-Dimer. In additional, complete blood count preformed for each blood sample by automatic RUBY system.
Results
Blood tests showed, the level of D-dimer, WBC, platelets were higher in cases (1497ng/ml, 12.48 X109/L, 388.69 X109/L respectively) compared to control group (220 ng/ml, 8.93 X109/L, 328.21 X109/L respectively) while the mean of lymphocytes and hemoglobin were lower in the patient group (11.67% and 11.97 g/dl respectively) in comparison to control group (15.12% and 12.55 g/dl respectively). Immunologically, concentration of IL-17 was higher in the cases with severe disease (213.28pg/ml) compared to control group (100.69pg/ml).
In Conclusion
The results showed that an increase in the concentration of IL-17 coincided with a positive linear increase in D-Dimer, WBC and platelets, and to a lesser extent with lymphocytes and hemoglobin.
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