The modification of Cowpea Mosaic Virus (CPMV) with Aspirin and Its application as Anti- Infectious Drugs
University of Babylon, College of Science, Chemistry Department, Babylon, Iraq.
University of Babylon, College of Science, Chemistry Department, Babylon, Iraq.
Medical laboratories Techniques Department, Al-Mustaqbal University college, Babylon, lraq.
University of Babylon, College of Science, Chemistry Department, Babylon, Iraq.
Abstract
Currently, Infectious diseases are of the most concern and threat to the entire world. They are caused by bacterial, fungal, parasitic and viral infections. Now days, nanotechnology-based drug delivery systems are in use to overcome these challenges. The current research focuses on the use of aspirin as an anti-inflammatory drug, both with and without conjugation to the outer surface of (CPMV) in order to enhance the efficacy of therapeutics and reduce or eliminate the drug resistance which is the biggest biological problem in the treatment of infectious diseases.
Due to the resistance to commercially available medications, the particle used as an Aspirin (AS) carrier. When compared to free Aspirin, which has limited anti-infectious effect, the CPMV-AS conjugate, in which 160 molecules are covalently linked to the exterior surface amines of the viral nanoparticle (VNP), showed the strongest suppression against both gram-positive and gram-negative bacteria.
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