Relation of Some Immunological Markers (IL 4, 12 and 23) with Toxoplasmosis in Aborted Women
Al-Zahra Teaching Hospital, Wasit Health Directorate, Iraqi Ministry of Health, Wasit, Iraq.
Jabir Ibn Hayyan University of Medical and Pharmaceutical Sciences, Najaf, Iraq
Ministry of Science and Technology, Baghdad, Iraq
Alshaheed fayrooz hospital, Wasit Health Directorate, Iraqi Ministry of Health, Wasit, Iraq
Dhi-Qar Health Directorate, Iraqi Ministry of Health, Nasiriya, Iraq
Dhi-Qar Health Directorate, Iraqi Ministry of Health, Nasiriya, Iraq
Department of Forensic Sciences, College of Medical Techniques, Al-Farahidi university, Baghdad, iraq
Dhi-Qar Health Directorate, Iraqi Ministry of Health, Nasiriya, Iraq
Dhi-Qar Health Directorate, Iraqi Ministry of Health, Nasiriya, Iraq
Dhi-Qar Health Directorate, Iraqi Ministry of Health, Nasiriya, Iraq
Abstract
Background
Toxoplasma gondii is a major cause of abortion in pregnant women. Toxoplasmosis infection in the mother during pregnancy is frequently associated with transplacental transmission of the parasite to the fetus. The purpose of this study Aims of this study determine and compared the different concentrations level of interleukin (IL) 4, 12 &23 in patients with toxoplasmosis and control groups.
Materials and Methods
From September 2020 to May 2021, a case-control study was carried out in Thi-Qar province to estimate the role of Toxoplasmosis in the occurrence of abortion among pregnant women. The current study included 120 aborted women as well as 20 healthy women as controls (Non pregnant and have no clinical history of abortion). All of these cases involved only females of reproductive age (16-44 years). Toxo-IgM and Toxo-IgG antibodies were tested first with a latex agglutination test (LAT) to detect positive samples, followed by an Enzyme Linked Immunesorbent Assay (ELISA) to detect IgG and IgM antibodies in both groups. CUSABIO method for measuring human interferon (IFN-) and 2-human cluster of differentiation 4 (CD4) (USA)
Results
IL-12 value in a patient with IgM was (48.59) which is significantly higher than the control patient value (38.69). Also, IL12 value of patients with Toxo IgG (57.48) was significantly higher than the control patient. IL-23 values of a patient with Toxo- IgG, and Toxo- IgM were (77.92&57.92) respectively which is significantly higher than the control patient value (38.38). IL-4 value in a patient with Toxo- IgG was (35.83) and Toxo- IgM was (42.67) which is significantly higher than the control patient value (25.90).
Conclusion
The concentration level of IL-4, IL-23 & IL-12 were increased in each acute and chronic infection compared with the control group).
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