Formulation and In-Vitro Evaluation of Orally Disintegrating Tablets (ODTs) of Zolpidem for Rapid Onset of Action in Insomnia
DOI:
https://doi.org/10.48047/Keywords:
Zolpidem, Orally Disintegrating Tablets, Insomnia, Superdisintegrants, In-vitro Evaluation, Rapid Onset of Action, Direct Compression, Drug Release.Abstract
Zolpidem is a non-benzodiazepine hypnotic agent used for short-term treatment of insomnia. It undergoes extensive first-pass metabolism, leading to reduced bioavailability and delayed onset of action when administered orally in conventional tablet form. Orally Disintegrating Tablets (ODTs) offer a promising alternative
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References
Baglioni, C., Battagliese, G., Feige, B., Spiegelhalder, K., Nissen, C., Voderholzer, U., ... & Riemann, D. (2011). Insomnia as a predictor of depression: A meta-analytic evaluation of longitudinal epidemiological studies. Journal of Affective Disorders, 135(1–3), 10–19. https://doi.org/10.1016/j.jad.2011.01.011
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