Method Development and Validation of RP-HPLC for Simultaneous Estimation of Nirmatrelvir and Ritonavir in Pharmaceutical Dosage Form

Authors

  • Bethina Venkata Sruthi, Edward Raju Gope, Shaik Munnisha Begam, Shaik Ayesha, G. Manisha, Kavala Nageswara Rao, Raghava Doonaboyina , Nirmala Korukola Author

DOI:

https://doi.org/10.48047/

Keywords:

RP-HPLC, Nirmatrelvir, Ritonavir, Method Validation, Pharmaceutical Analysis.

Abstract

The present study focuses on the development and validation of a simple, precise, accurate, and economical reversed-phase high-performance liquid chromatography (RP-HPLC) method for the  simultaneous estimation of Nirmatrelvir and Ritonavir in pharmaceutical dosage forms.

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References

• Shaik, R.P.; Puttagunta, S.B.; Kothapalli, C.B.; Awen, B.Z.S.; Challa, B.R. A validated LC–MS/MS method for the determination of tolterodine and its metabolite in rat plasma and application to pharmacokinetic study. J. Pharm. Anal. 2013, 3, 489–499.

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Published

2026-04-11

How to Cite

Bethina Venkata Sruthi, Edward Raju Gope, Shaik Munnisha Begam, Shaik Ayesha, G. Manisha, Kavala Nageswara Rao, Raghava Doonaboyina , Nirmala Korukola. (2026). Method Development and Validation of RP-HPLC for Simultaneous Estimation of Nirmatrelvir and Ritonavir in Pharmaceutical Dosage Form . History of Medicine, 12(1), 68-83. https://doi.org/10.48047/