Evaluation of the synergistic effects of Lavandula angustifolia extract in combination with antibiotics against multidrug-resistant Enterococcus faecalis and its in-vitro antioxidant activity
DOI:
https://doi.org/10.48047/HM.V12.I1.2026.269-285Keywords:
Medicinal plant, Lavandula angustifolia extract, synergism, additive, MDRsAbstract
Lavandula angustifolia (lavender) is a perennial shrub known for its antibacterial and antioxidant properties, largely due to its essential oils and extracts. This study evaluated these properties using plant material collected in Lahore, Pakistan and processed at Minhaj University Lahore. The dried plant was extracted with 80% ethanol and chloroform and the crude extracts were tested against multidrug-resistant Enterococcus faecalis. Antibacterial activity was assessed via MIC and disk diffusion methods, while antioxidant activity was measured through hydrogen peroxide assay. The results showed significant antibacterial effects, particularly when combined with antibiotics, indicating synergistic interactions. The ethanolic extract achieved 73% inhibition while the chloroform extract showed 77.6% inhibition at a concentration of 5 mg/ml, with both also exhibiting strong antioxidant activity. These findings highlight Lavandula angustifolia as a promising source of bioactive compounds for the treatment of drug-resistant bacteria and the development of natural antioxidants.
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Copyright (c) 2026 Rimsha Shafiq, Muhammad Daniyal Javed, Umair Akhtar, Areeba Naveed, Muhammad Haseeb Gohar, HafIz Khawar, Hafiza Nida Shehzadi, Saba Abbas (Author)
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