A Study to Detect Carbapenemase Production by Phenotypic Method in Carbapenem-Resistant Enterobacteriaceae and Its Effect on Antimicrobial Susceptibility Pattern in a Tertiary Care Hospital, Rajasthan
DOI:
https://doi.org/10.48047/Keywords:
Carbapenem-resistant Enterobacterales (CRE); Carbapenemase production; Modified Carbapenem Inactivation Method (mCIM); Antimicrobial susceptibility; Multidrug resistance; Klebsiella pneumoniae; Escherichia coli; Tertiary care hospital; RajasthanAbstract
Background: Carbapenem-resistant Enterobacterales (CRE) have emerged as a critical global public health threat, with mortality rates in CRE bloodstream infections ranging from 40–50%. Carbapenems serve as lastresort antibiotics; their compromise by carbapenemase-producing organisms severely limits therapeutic options. The present study was undertaken to detect carbapenemase production by phenotypic method (mCIM) in carbapenem-resistant Enterobacteriaceae and to determine its effect on the antimicrobialsusceptibility pattern in a tertiary care hospital in Rajasthan, India.
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References
Gupta N, Limbago BM, Patel JB, Kallen AJ. Carbapenem-resistant Enterobacteriaceae: epidemiology and
prevention. Clin Infect Dis. 2011;53(1):60-67.
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